(Archives of Toxicology) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment
To determine the best way to select predictive groups of genes, we used published microarray data from dose-response studies on six chemicals in rats exposed orally for 5, 14, 28, and 90 days. We evaluated eight approaches for selecting genes for POD derivation and three previously proposed approaches (the lowest …