Gene-metabolite network linked to inhibited bioenergetics in association with spaceflight induced loss of quadriceps muscle
Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of muscle atrophy caused by continued unloading. Under the Rodent Research Program of NASA we assayed the genomic and metabolomics perturbations in the quadriceps of C57BL/6j male mice that lived on the spaceflight (FLT) …