Case study in 21st century ecotoxicology:  using in vitro aromatase inhibition data to predict short term in vivo responses in adult female fish
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo) responses to chemicals shown to inhibit the enzyme aromatase in a non-animal (in vitro) screening assays. Aromatase is an enzyme that plays a …